Additionally, we only included variants with two or more identical sequences in the analyses, which should ensure exclusion of random sequence errors.
Variants that are identical can be assumed to be IBD; even if there is recurrent mutation and the identical variants are not IBD, it is only the identity of the variant that matters when directly testing a putative causal variant.
Most progeny genomes of individual (clonal) RNA viruses generally differ from one another in having one or more mutations scattered randomly along their genomes; thus comprising a quasispecies cloud or swarm of related, but not identical variants.
Otherwise, they might have stopped sending wave after wave of almost identical variants of this malicious code.
The source and mechanisms involved in the emergence of these identical variants are not understood.
One possibility is that the identical variants arise from cells that have clonally expanded.
The dashed diagonal line indicates identical variant combinations on both trials.
It is clear that most speakers adopted similar if not identical variant combinations for both renditions.
Also, five more Hb variants, resulting from identical mutations on either one of the two human α-globin paralogue genes, were selected from HbVar database and/or the literature and included in this study, namely Hb Zurich-Hottingen/Hb Anadour (four cases), Hb Frankfurt (three cases), Hb Gerland (four cases), Hb St. Truiden/Hb Jeddah (four cases), and Hb Titusville (five cases).
Lamb 00186 was infected with the more virulent variant 1 (identical to GenBank M73220) and lamb 0054 with variant 2 (identical to GenBank AF336220) [ 48], to be referred to as ApNorLamb-V1 and -V2 from here on.
