Sentence examples for more hyperpolarized potentials from inspiring English sources
In HD, it appears that NMDA receptors of MSSNs are potentially activated at more hyperpolarized potentials, which could be deleterious for the cell.
Because cells tend to become unstable with extreme hyperpolarizations and because Ih reaches steady-state more quickly at more hyperpolarized potentials, we used shorter (4s) steps at −113 and −123 mV.
Experimental neurons had a lower RMP, and inward and outward rectification occurred at more hyperpolarized potentials.
Similar to luteolin, myricetin shifted the conductance/voltage relationship to facilitate channel opening at more hyperpolarized potentials (Fig. S2B), and slowed deactivation (Fig. S2C).
However, if we look into more hyperpolarized potentials the PSPśamplitude departs from the linearity of the voltage dependence and decreases, revealing an accumulation of values at low amplitudes corresponding to down states.
2 µM BmK IT2 strongly shifted the activation of DmNav1, the sodium channel from Drosophila, to more hyperpolarized potentials; whereas it hardly affected the gating properties of rNav1.2, rNav1.3 and mNav1.6, three mammalian central neuronal sodium channel subtypes.
Their rheobase is decreased because of a more hyperpolarized voltage threshold for spiking.
Subunits γ1 (LRRC26), γ2 (LRRC52), γ3 (LRRC55), and γ4 (LRRC38) produce a shift towards more hyperpolarized membrane potentials, even in the absence of intracellular calcium and transcripts for all four subunits are detectable in human testis (Yan and Aldrich, 2010, 2012; Yang et al., 2011).
To test whether these activity patterns differed between groups because of the more hyperpolarized membrane potential of RPeD1 neurons in the U-type dsRNA group, we injected a compensatory current to depolarize the membrane potential to −45 mV, thereby approximating the RMP of the control cells (Figure 2B).
Quantal content was calculated by dividing the average eEPSC amplitude by the average mini amplitude, corrected for the more hyperpolarized holding potential (amplitude reduction to 75%; Hallermann et al., 2010).
They tended to have slightly more hyperpolarized resting membrane potentials, but were otherwise very similar to group 1 interneurons (Table 1).
