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Two scientific papers published this week suggest that there might be many more human genes than thought, or at least that the human genome has hidden levels of complexity that are only starting to be revealed.
The significance of genetics only promises to become greater as the structure and function of more and more human genes are characterized.
Another initiative would create a collection of antibodies for the primary proteins made by the 30,000 or more human genes.
Syntenator aligned more human genes than Blockfinder (dark gray bars).
Because the human genome is better characterised than the rat genome, more human genes are usually displayed.
The most striking trend with decreasing age is that more and more human genes are not annotated in GO or KEGG.
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Are more ancient human genes really involved in more basal cellular functions?
Pathogenic mutations have been described in slightly more than 5,000 human genes (Human Gene Mutation Database. http://www.hgmd.cf.ac.uk/ac/hahaha.php).hgmd.cf.ac.uk/ac/hahaha.php
Our higher sensitivity may be at the expense of specificity, because in total we predicted about three times more human miRNA genes than RegEx (3441 compared to 976).
It has contributed to the identification of, arguably, more human aging genes than any other model organism [ 45].
The remaining 13 clades contained two or more paralogous human genes, that is, genes that have amplified up from a common progenitor during vertebrate evolution (Fig. 2, 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com