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In the Cahill study [12], all surgical patients were excluded to select a more homogenous study population, as surgical patients typically are more difficult to feed, have lower tolerance to EN, and receive less nutrition compared to medical patients.
A larger, more homogenous study group would have been preferable but was not possible at the time of the study.
Furthermore, more homogenous study designs and standardized outcomes could generate findings that are more useful for making recommendations to the general population.
It suggests that when working with a more homogenous study population, a high R can be associated with a smaller %TEM.
Therefore, in order to have a more homogenous study population and avoid inserting potential confounders in the analysis we focused only on TF patients.
Although a more homogenous study population improves performance and stability of a risk prediction model, this may also limit its general applicability.
Similar(51)
The reasons for including such studies were to improve the statistical power of meta-analysis and to perform the analyses on subgroups of more homogenous studies.
Therefore, more homogenous studies on the association between identical CIMP and cancers are needed in the future to allow for the meta-analysis on the prognostic value of CIMP in colorectal cancer.
Larger and more homogenous studies are still needed to replicate the findings obtained so far, or to analyze other genetic variations to get clearer insights into how IM treatment can be tailored to each patient's genetics.
To ascertain that the biomarker findings are not biased by the SpA subtype and that the data can be extrapolated to more homogenous SpA study populations, we performed two additional sets of analysis.
In this respect, the group analyzed in our study is more homogenous, as all study participants were treated according to the same regimen (tacrolimus + mycofelate mofetil + steroids), which may translate into an increased sensitivity of the analysis.
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