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Age can be used to select samples with larger genetic effect sizes and more homogenous phenotypes, which may increase statistical power.
Since the phenotypic heterogeneity of the disorder is probably at fault for the lack of agreement between studies, some groups have resorted to using more homogenous phenotypes - such as lithium response - as a selection criterion.
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Composite measures such as the Rockwood frailty index (Rockwood & Mitnitski, 2007) combine several of those clinical traits to form a more homogenous phenotype – frailty – from its diverse appearance.
The discrepancy between the outcome of the current study and the aforementioned placebo-controlled study might possibly be explained by the presumption that chronically inflamed patients represent a more homogenous immunological phenotype regarding the importance of monocytes for driving the inflammation.
Reduction of extrinsic noise, which for example could occur through stronger feedback control on a promoter (Lestas et al., 2010), resulted in a population with a tighter, more homogenous distribution of phenotypes.
In this study we will address this issue through the assessment of the homogeneity of the ASD phenotype in genetically more homogenous samples.
Also, at 12 months significant clinical differences between baseline groups of liver phenotype had vanished (Table 1) making the study material more homogenous and similar to the general population (NHANES) that showed positive associations between liver enzymes and POPs [ 33].
Thorough evaluation of men with familial TGCT and their unaffected relatives may help to further define the familial testicular cancer syndrome phenotype, and might permit stratifying the population at familial risk into more homogenous, discrete clinical categories with similar genetic aetiologies, thereby improving the statistical power of gene discovery efforts.
It is much more homogenous".
"Our applicant pools are more homogenous than ever," he said.
Republicans, on the other hand, tend to be more homogenous.
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