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The more homogenous expression of Nanog in Tcf3 mutants indicates that repression by Tcf3 contributes significantly to the heterogeneous and fluctuating pattern observed in serum [24], [26].
Blood samples from the different individuals, however, exhibited a far more homogenous expression pattern.
This is presumably due to the more homogenous expression of CLB3 in cells where expression is driven from the GAL1-10 promoter.
Therefore, we propose that enhanced STAT3 phosphorylation leads to the more homogenous expression of pluripotency factors such as Nanog, Klf4, and Esrrb.
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As we have recently shown, however, ccRCC tumors may also reveal more homogenous gene expression patterns [6].
Building on the goal of more homogenous gene expression of reprogramming factors, Mathison et al. [ 34] also generated a single-promoter polycistronic vector encoding GMT and 2A self-cleaving peptides.
In contrast to the multiple retroviral deliveries of GMT factors used by Qian et al. [ 3], Inagawa et al. [ 33] used a single promoter polycistronic retrovirus containing GMT with intervening sequences of 2A self-cleaving peptides, which permitted more homogenous GMT expression.
We noted that unlike the wt-cells, which had distinct high and low CD24 populations, the wnt1 expressing cells had a more homogenous and lower expression of CD24, precluding their further sub-division based on this marker.
The main differences between lymph and skin DC were the higher expression of CD16 on CD163low lymph DC (populations (3) and (4)) compared to their skin counterparts, a higher general expression of CD206 and a more homogenous weak to null expression of CD209 in all the lymph DC subpopulations (Figure 2).
Cell lines are a more homogenous population and BCAS3 expression in glioma lines is suggestive of expression in non-vascular neuroectodermal cells.
In radicular and folicullar cysts, Zustin et al [ 5] found podoplanin expression more homogenous, diffused at cytoplasm and membrane, in epithelial basal and parabasal layer.
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