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AT a time when cookbook subjects have never been more highly specific -- a 494-page book on eggs will be hitting the shelves in May -- it is difficult to get away with writing a cookbook of eclectic recipes.
Although traditional chemical conjugations have dominated in the past, more and more highly specific coupling strategies are becoming available that are based on protein engineering.
Second, use of radiotracers with more highly specific activity is more likely to ensure that the radiolabeled compound does not elicit any pharmacological effects when administered.
A more recent study, using newer and more highly specific β3 agonists (licensed for other conditions), however, suggests that pharmacological manipulation of BAT remains a viable option.
The sensitivity/specificity profiles of each marker (76%/94% for temperature, 68%/91% for PCT, and 92%/70% for CRP) led to a composite score (0.068 × D0 PCT + 0.005 × D0 CRP + 0.7 × temperature) more highly specific than each component (AUC of 0.90 and sensitivity/specificity of 80%/97%).
We then classified patients as having typical clinical features of acromegaly if they exhibited two or more highly specific features; mild features if they exhibited one highly specific feature or three associated features; and no features if they exhibited no highly specific features and not more than two associated features.
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The more interesting highly specific regions are summarized in Table 4 and ordered taking into account the specificity score found in the eight compared strains.
In contrast, they were more highly source specific; in particular, isolates from humans exhibited almost no commonality with isolates from food animals or foods.
But experts in the field say that a new National Cancer Institute initiative, the Ovarian Cancer Early Detection Program, promises to yield more sensitive, highly specific -- and thus accurate -- screening tests for ovarian cancer within the next five years.
For dogs, however, he argues that object labels may be nothing more than highly specific commands to fetch particular objects.
Both NT families possess subtype-dependent nucleoside specificities and tissue distributions, while CNTs are more highly subtype-specific for their substrates and distributions than ENTs (Gray et al., 2004b; Paproski et al., 2013).
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