Sentence examples for more highly metastatic from inspiring English sources
Our selection approach has produced more highly metastatic, migratory and invasive sublines.
These data show that Myo10, Myo9b, and Myo1b are overexpressed in more highly metastatic cell lines and in metastatic tissue.
These findings suggest that NE-NSCLC, analogous to SCLC is more highly metastatic than non-NE-NSCLC.
On the other hand, the more highly metastatic melanoma cell line, C8161.9, expressed over 2× higher levels of αvβ5 than M14.
Therefore, Myo1b, Myo9b, Myo10, and Myo18a each contribute to the morphology and migration of more highly metastatic PC-3 cells, with each myosin having a specific effect on actin organization.
High endogenous levels of Myo1b in more highly metastatic cells might therefore increase cortical tension, allowing cells to move through stiff extracellular matrices in vivo, perhaps explaining why knockdown of Myo1b only affects migration in 3D but not 2D.
eEF1A1 has been shown to determine the susceptibility of a number of independent cell lines to chemical- and UV-induced transformation [ 13] and has been identified as an actin binding protein in rat breast tumour cells, where it was found to be more highly expressed in metastatic than non-metastatic cells [ 14].
CST6 is more highly expressed in metastatic cancers than in primary cancers, and CST7 is upregulated in murine liver metastatic cancers.
Our findings confirmed that CD45+F4/8 0+macrophages were more highly abundant in metastatic tumors in ICAM-1−/− mice than in WT mice.
Importantly, Maher and colleagues revealed that some transcription-mediated fusion transcripts such as SLC45A3-ELK4 are more highly expressed in metastatic prostate cancers compared to benign cells [ 12].
In focusing on how metastatic properties of tumor cells might influence Pa infection, we found that ExoS translocation was more efficient in highly metastatic MTLn3 cells as compared to non-metastatic MTC cells.
