Sentence examples for more highly constrained from inspiring English sources

In principle, this might better elicit antibodies against a more highly constrained, but less immunogenic, neutralizing determinant.

This suggests that group I intron fixation may be even more highly constrained by the exon context than are spliceosomal introns.

We hypothesized that, over the generations grown in culture (rather than on host tissue), selection on virulence-associated genes may be relaxed and could be evidenced by an elevated substitution rate relative to more highly constrained genes.

Residual stresses are more likely to be significant in repair welds since they are small, more highly constrained and faster cooling than large construction welds.

To write a Fib, a more complicated version of the classic, highly constrained haiku, the poet composes a six (or more) line poem that has the correct number of syllables in each line corresponding to each digit in the Fibonacci sequence.

Briefly, highly constrained positions are more conserved.

It holds much more generally, even for the most highly constrained pairs.

The allele frequency distribution of PTCs is also more skewed than that observed for highly constrained nonsynonymous polymorphisms (fig. 1, chi-square test, P < 10−11), whereas the distribution for SCLs was neither more nor less skewed than nonsynonymous polymorphisms (fig. 1).

We show that paralogs are more asymmetric in: a) clades orthologous to highly constrained singleton genes; b) genes with high expression level; c) genes with ubiquitous expression and d) non-tandem duplications.

Alternatively, proteins that are already performing important functions are highly constrained and therefore might have more need of chaperone-assisted folding following the fixation of functionally innovative mutations.

If two samples are not the same at an exonic position, which is highly constrained in the population, this contributes more to the total distance, because such an event has a higher probability of being a genotyping error than divergent genotypes at a highly variable site of the exome.