As expected, the results of this analysis coincided well with the amino acid conservation, with more highly conserved residues predicted to have greater evolutionary significance.
Since protein domains define specific, conserved biochemical functions, they tend to be more highly conserved than entire protein sequences.
Simple satellite sequences appear to be more highly conserved than coding regions of the genome, on a per nucleotide basis.
The tethering factors employed at different steps are evolutionarily unrelated, yet their function seems to be closely tied to the more highly conserved Rab GTPases.
Thus, contrary to generally accepted descriptions of there being greater evolutionary pressure to preserve the EC domain, it is the 7TM domain that is more highly conserved.
Although B*27/57neg LTNP/EC did not target more highly conserved epitopes, their CD8+ T-cell cytotoxic capacity was significantly higher than progressors.
The pDicer coding sequence was found to be highly conserved, and phylogenetic analysis showed that pDicer is more highly conserved to human Dicer (hDicer) than the mouse homolog.
AS events detected in the brain are more highly conserved than those detected in other tissues, suggesting that they more often provide conserved functions.
Over the last thirty years such genetic screens have been used to elucidate the cell cycle, secretory pathway, and many more highly conserved aspects of eukaryotic cell biology (1-5).
This suggests that the introns are more highly conserved than the exons, the coding parts of the genes.
They are currently trying to express more highly conserved influenza antigens in recombinant vesicular stomatitis virus (rVSV) vectors in order to elicit robust T cell and antibody responses to those antigens.
