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Therefore, further multicentered research involving a larger and more heterogeneous study sample is needed.
A more heterogeneous study sample would have been helpful in this regard.
More research, with more heterogeneous study samples, is needed to establish the criterion validity of the 4DSQ Anxiety scale.
Last, more diversity in the geographic origin of the strains and a mix of nonimmune and semiimmune patients would lead to more heterogeneous study groups.
A closer look at the study centers (Additional file 1: e-Table S1) shows more heterogeneous study centers in RHINE than in I-ECRHS and ISAYA.
The association between MSI phenotype and high lymph node yield as was observed in the present study has been reported before in 2 smaller and more heterogeneous study populations compared with the present one.
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These similar or higher ICC values might be explained by the current study consisted of a much more heterogeneous study-population in both groups than the very small study-population in the Spiteri et al. study.
Conclusions: Further research in this area requires a more ingenious approach such as use of more socially heterogeneous study populations than those usually found in Denmark.
PFOS exposure trends were considerably more heterogeneous; a study from Norway using pooled serum samples reported an increase in young females' PFOS levels from 2.5 ng/mL in 1976 to 25 ng/mL in 1998 (Haug et al. 2009), but during almost the same period we observed a very limited increase, with CIs including no change.
Results were more heterogeneous for cohort studies than other study types.
This work highlighted that breast cancer is considerably more heterogeneous than earlier studies had portrayed (Chin et al, 2006) and showed the existence of a low genomic instability index (defined as the fraction of the genome altered) tumour cohort consisting disproportionately of ER-negative and basal samples.
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more heterogeneous design
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