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Bent's meta-analysis [ 17] included a considerably more heterogeneous population than did our study, but did not include any analysis of heterogeneity.
But if the findings can be replicated in a more heterogeneous population, researchers could create a blood test to predict who might develop the disease.
In other countries, because of such factors as a more heterogeneous population, a higher level of demographic growth, and greater geographical barriers, the results of great efforts have been less than impressive.
Taken together, we expanded NK cells with significant up-regulation of activating NKG2D and moderate enhancement of cytotoxicity, with IFN-γ producing ability and a more heterogeneous population of NK cells.
In therapeutic areas where it may be difficult to continually recruit from a homogeneous population, this assumption may not be valid; patients randomized toward the end of enrollment may derive from a more heterogeneous population and negatively impact the power of a study.
Population of young-treated flies became more heterogeneous, population of old-treated flies became less heterogeneous, and both populations became more robust in average after stress.
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Conversely, LNA transfection gave us much more heterogeneous populations of miR-122 activity, which is probably based on transfection efficiency differences (Supplementary Fig. 1c,d).
But "common goals" are much harder to come by in larger, more heterogeneous populations.
We suggest that this population isolate is suitable to identify rare variants associated with complex phenotypes that may be difficult to study in larger but more heterogeneous populations.
The length of LD map is inversely related to the extent of LD over a given chromosomal segment, therefore shorter LD maps are observed in population isolates compared with more heterogeneous populations.
Further studies, with larger sample sizes distributed across larger, more heterogeneous populations in a diversity of settings will be required to determine whether these results are reproducible and broadly applicable.
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