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Sensitivity suffered in these initial studies, partly due to the low resolution of conventional scintigraphy, as well as the lower and more heterogeneous expression of sstr2 on breast carcinoma compared to NETs (Alberini et al. 2000; van Eijck et al. 1994; Wang et al. 2008).
In this context, the findings of progenitor/differentiation gene homogenization after vaccination, coupled with more heterogeneous expression of these genes under conditions of T cell deficiency in GL26, are particularly intriguing in that they point to a previously undocumented ability of immune activity to constrain tumor genetic variation.
A more heterogeneous expression pattern of these genes were observed in tumor samples.
The slightly more heterogeneous expression distribution with pCUP1 EC 1118 might provide a possible explanation.
In doing so, small and/or maybe more heterogeneous expression changes may not be detected.
These cells were almost uniformly LHR-negative, whereas they displayed a more heterogeneous expression of PDGFR-α.
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Recent single cell analyses revealed much more heterogeneous gene expression in iPSCs than in ES cells [ 34].
Subsequent studies, based primarily on individual probands rather than families, have reported exceptions and more heterogeneous cardiac expression within a given gene or mutation, although recent reports from the UK suggest a higher risk of sudden death in TNNT2 vs. MYBPC3 families (0.93 vs. 0.46% per year).
Results at 14 days pi (co-infected bees) revealed a more heterogeneous pattern of expression though no differences in expression were significant across treatment groups (Mann–Whitney U Test, p > 0.05; Additional file 1: Figure S3B).
This observation would suggest that duplicate cores from the same tumour have similar levels of ER expression as determined by image analysis, thus indicating the homogeneous nature of ER staining, whilst PR expression would be associated with a more heterogeneous pattern of expression.
Unlike scFv which always self-aggregates, nanobody is more soluble after heterogeneous expression (Kong et al. 2014).
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