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Many current innovations are: using technology differently; more heavily constrained; forcing new business models and increasingly being shaped by drivers.
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Indeed, the packing of residues is so precise that we may think of proteins as solutions to 3D "jigsaw puzzles," wherein the outside pieces make fewer contacts with other pieces and are therefore more free to change, whereas the buried inside pieces are heavily constrained by their densely packed environment (Richards 1974).
Perhaps more germanely, the ability of Scotland to borrow in its own right would remain heavily constrained.
Most of the genes are located on a slow evolving linear chromosome, heavily constrained in its structure, while other genes are stored on the more flexible, fast evolving, and heavily recombining plasmids[ 43, 49, 50].
Even then, the use of drones is heavily constrained.
And even then, the use of drones is heavily constrained.
Your choices after university are actually quite limited, heavily constrained by your ability to pay.
That's because the legislation's design was heavily constrained from the outset.
It was heavily constrained in its passage through the House of Commons with some serious doubts about the process".
And it can only have disastrous consequences at a time when pressures are building and costs heavily constrained.
Cities that are heavily constrained by the green belt such as Oxford, London and Cambridge have some of the most unaffordable homes in the in the country.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com