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"Extrapolating from these data into a more global effect can't be done". Foster advised people not to get unduly concerned as a result of Figueiro's research.
Hence, we hypothesize that a more global effect induced by the disulfide in the force-stressed protein can decrease the mechanical stability of the domains.
Black carbon has a more global effect as well, however, and climate scientists have recently begun to consider reducing black carbon emissions as a viable way to slow the pace of climate change.
A less likely theory would be a frank baseline NAD deficiency due to genetics or malnutrition, but one would expect a more global effect on health rather than just alcohol-induced hypoglycemic coma.
We extended these studies to assess a more global effect on lung monocyte biology.
We sought to determine whether the NMDA current inhibition is solely dependent on Homer1a, or rather due to a more global effect on the scaffolding complex.
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This is expected, since distortion due to BER is local while compression has more global effects.
It will be interesting to expand these studies to include evaluation of more global effects of AR rescue using different concentrations of ligand, or with ligands other than the endogenous AR agonists.
Next, we addressed whether compromised KDAC function had more global effects on Hsp90 client protein regulation.
Degeneration in the light of osteoarthritis may be different from the more global effects of wear and tear.
In contrast, mutational changes in muscle activity could have much more global effects, affecting all muscles, related or not to food processing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com