Sentence examples for more global defect from inspiring English sources

We also found downregulation of an additional CTLR, DC-SIGN, indicating a more global defect in expression of members of this family.

In this report, we demonstrate that the KB-CP20 cells have a more global defect in the uptake of a variety of radioactively labelled compounds.

The workshop has also discussed the more global defects at the cellular levels such as in celiac disease, microvillus inclusion disease, or cystic fibrosis which also elicit chronic diarrhea [7 9].

In addition, non-HLA genes that are associated with more global defects in immune regulation are also required for disease development and are thought to underlie the clustering of multiple autoimmune disorders in families and individuals with T1D [ 39].

Therefore, although there is a major impact on the myeloid lineage with the consequent neutropenia, there are features suggestive of a more global haematopoietic defect.

In one RTS patient, with the appropriate sample being available (RT2), peripheral blood progenitor studies showed a reduction in both myeloid and erythroid progenitors (Supplementary Material, Table S2), again providing evidence for a more global haematopoietic defect.

It is not clear why widespread arteriopathy does not cause more global organ defects.

However, these results could not be recapitulated using RNAi knockdown of Dube3a in muscle or neurons alone, suggesting more global developmental defects contribute to this phenotype.

Notching of the RAA is also uncommon and in this patient may reflect a more global right atrial field defect during cardiogenesis.

Although our expression data are more consistent with a global defect in neuronal expression in Taf9b KO mice, the lack of spatial information for the defects in gene expression in the spinal cord in our experiments does not allow us to completely rule out that certain neuronal types may be more severely affected than others.

"More global, national, international.