Given that ISs can promote recombination in bacterial strains [ 71], one can include recombination in future models to study how it influences the IS dynamics by creating more genomic variation.
Besides these small-scale changes, group II phages have obviously also used shuffling of larger DNA fragments resulting in more pronounced genomic variations.
However, these CNVRs are most likely to be aberrant regions in the reference boar since this is of a different breed (i.e. Hampshire), and probably more structural genomic variation is present between breeds than within the same breed, since all the test boars are of the Duroc breed.
The whole genome sequencing has been proposed as a sort of "gold standard" for strain typing in M. tuberculosis since it clarifies previous strain typing approaches used for phylogenetic and epidemiologic studies and provides more detailed genomic variation information.
As sequencing technology improves, more of our genomic variations will come into view.
In the study, the investigators analyzed the genomic sequences, or more accurately the genomic variations, from over 1,100 individuals to examine the level of variation in miRNAs.
It is likely that a larger sample with diverse lineages and countries of origin would probably reveal more information on genomic variations and evolution of drug-resistant M. tuberculosis strains.
This will facilitate a number of investigations, including a more efficient approach to GWASs to investigate preterm birth and/or resequencing genomic regions with a more dense coalition of genomic variations.
More studies to characterize genomic variations that affect phenotypes of SCD and their application in primary and secondary preventions, as well as prospective studies on genomic-based therapeutic interventions, could allow Africa, where two-thirds of SCD patients live, play a major global role in hemoglobinopathies research.
