However, 4nAT presented more genomic variations compared with their parents than 2nF1.
Shown in Figure 1 is one exemplary syntenic block, fragments mapped in small pieces are usually located at the flanking regions or untranslated regions (UTRs) of genes, indicating that more genomic variations occur in regulatory regions or UTRs of genes than in coding regions.
However, these CNVRs are most likely to be aberrant regions in the reference boar since this is of a different breed (i.e. Hampshire), and probably more structural genomic variation is present between breeds than within the same breed, since all the test boars are of the Duroc breed.
The whole genome sequencing has been proposed as a sort of "gold standard" for strain typing in M. tuberculosis since it clarifies previous strain typing approaches used for phylogenetic and epidemiologic studies and provides more detailed genomic variation information.
Besides these small-scale changes, group II phages have obviously also used shuffling of larger DNA fragments resulting in more pronounced genomic variations.
Although gene content variation is common in eukaryotes, it is likely a more important source of genomic variation in bacteria, in which horizontal gene transfer (HGT) is common (reviewed in Gogarten and Townsend 2005; Kuo and Ochman 2009b; Zhaxybayeva and Doolittle 2011).
In contrast, more and more data are available demonstrating intertissular genomic variation for numerical chromosome aneuploidy contributing to mosaicism as a global mechanism for example in germ cells, placenta, human brain, skin, liver and blood [9], [10], [11].
Additionally, with increasing evidence of polymorphic genomic variation in genome it is more important to critically look at structural changes and its influence on gene expression status.
This is particularly true of very large datasets, which contain more genomic regions, and thus more variation in rates and patterns of molecular evolution than smaller datasets.
As sequencing technology improves, more of our genomic variations will come into view.
