Sentence examples for more genomic aberrations from inspiring English sources

The BRCA2-like aCGH profile is characterised by even more genomic aberrations.

However, in real data, the aberration varies across samples: some tumors have more genomic aberrations during oncogenesis than others.

In aCGH we found that pT1 tumours had more genomic aberrations than pTa tumours, which strengthens the hypothesis that bladder tumours accumulate genetic alterations with progression of disease.

In addition, it appears that in a p53 deficient background, Brca1 loss gives rise to more genomic aberrations than does Brca2 loss.

Using single cell comparative genomic hybridization this group has demonstrated that EpCAM+ cells harbored significantly more genomic aberrations than CK+ cells, which may explain their high metastatic potential [ 16].

In support of these studies, we observed significantly more genomic aberrations in patients with intermediate JAK2V617F allele burden (1 85%) compared with patients with wild-type JAK2 (<1% JAK2V617F) (data not shown).

In terms of more recently recognised genomic aberrations observed in breast cancer, even for the most common ones such as PIK3CA mutations, only a few studies have interrogated their prevalence in metastatic disease in comparison to what is observed in primary tumours (Dupont Jensen et al, 2010; Gonzalez-Angulo et al, 2011; Kalinsky et al, 2011; Fumagalli et al, 2013).

This pathway is more frequently activated by genomic aberrations than any other signaling pathway in many tumor types.

Recently, more and more evidence showed that an increasing number of genomic aberrations were observed in the progression from normal sample to tumour sample [ 4].

Genomic aberrations can be more complex than deletions or amplifications.

Structural or quantitative changes within the genome are so-called genomic aberrations.