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It stands to reason that the more genetically complex an organism is, the loftier its place on the evolutionary tree.
This study provided an important view of the intratumor genetic landscape of a ccRCC carcinoma at the single-cell level and revealed that renal carcinomas may be more genetically complex than previously thought.
These developments are providing exciting opportunities for genetic mapping of human traits, ranging from accelerated discovery of mutations underlying relatively simple Mendelian disorders to more genetically complex human diseases.
Our pilot study demonstrates that ccRCC may be more genetically complex than previously thought and provides information that can lead to new ways to investigate individual tumors, with the aim of developing more effective cellular targeted therapies.
The higher percentage of mouse modules with three eQTLs and the lower number of genes in mouse modules (Fig. 4) indicates that the regulation of gene expression in mouse is more genetically complex than that in yeast.
LOAD has a heritable component, but has a more genetically complex mechanism than familial AD.
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Yet many oncologists remained skeptical that its success could be replicated in common cancers that were more aggressive and genetically complex.
Initial successes in relation to the genetics of AD were followed by frustration as investigators addressed the more common and genetically complex late-onset disease.
Researchers now prefer iPS cells because they can more effectively model genetically complex diseases, and because disease-specific ES cells have limited availability and can be logistically inconvenient to obtain [ 17]. bBut far from cutting community health centers out of the picture, grants might incentivize academic medical centers to partner with primary-care focused community health groups.
Moreover, what is currently considered to be EBLV-1b seems to include at least 4 lineages that are more genetically diverse and have a complex history.
The ST199-complex strains were significantly more genetically diverse than the strains belonging to other ST-complexes.
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more genetically unique
more genetically prone
more genetically susceptible
more genetically different
more genetically homogeneous
more genetically helpful
more genetically desirable
more genetically distinct
more genetically compatible
more genetically useful
more genetically important
more genetically unstable
more genetically close
more genetically meaningful
more genetically differentiated
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