More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease.
More generally, these observations suggest that IAV infection could trigger post-translational modifications of ER proteins, which in turn could mediate the remodeling of the endomembrane system and the formation of ICVs.
More generally, these observations delineate an approach that can be used to identify druggable synthetic lethal interactions with signaling pathways that are frequently activated in cancer but are difficult to target with the currently available small molecule inhibitors.
More generally, these observations raise important questions about the possible mechanisms that sustain the apparently high levels of diversity in populations of free-living protists.
More generally, these observations may lead to a re-examination of the low 5-HT diathesis theory, as a risk factor in the pathogenesis of impulsive aggression.
More generally, our observations support the notion that many loci of small effects influence variation in lymphocyte count and asthma susceptibility.
In HMMs, each state is associated with an outcome (more generally called observation) probability distribution.
More generally, this observation indicates that CSF may not accurately reflect the changes in the local intracellular or extracellular environment [ 10, 57].
More generally, the observation that entire complexes appear essential, henceforth referred to as modular essentiality, indicates that phenotypes can be associated with whole complexes and are not restricted to individual genes.
The teachers of the trained cohort may have more generally emphasised observation capacities, as an emergency call to the SAMU (or to an adult) required an oral description of the situation.
