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Its isoforms, which are created by alternative promoters and alternative splicing, have divergent abilities to transactivate p53 reporter genes and induce apoptosis [33] (suggesting a more generalized role).
This data suggests that the GPNMB/OA may play a more generalized role in promoting tumor progression, but does not preclude the possibility that certain GPNMB/OA-related functions specifically favor the development of bone metastases.
The effectiveness of the LT-IFN pathway against two distinct pathogens suggests a more generalized role in host defense.
Lam et al. [ 65] suggested a more generalized role of palmitoylation in the ER quality control of polytopic membrane proteins.
A number of experiments were conducted to evaluate if Akt1 was required for the localization of specific postsynaptic proteins, or rather served a more generalized role in directing a variety of proteins to this membrane specialization.
Similar(52)
The adjacent ice-binding proteins can be readily detected but are far-less abundant, perhaps pointing to a more generalized and important role for proteorhodopsin.
However, these conserved proteins, derived from a single gene, are expressed in numerous tissues indicative of a more generalized housekeeping function in addition to their tissue-specific roles.
High degree (>89%) of HOXC11 amino acid sequence conservation across the species indicates more generalized and mandatory biological roles of this protein in higher eukaryotes.
In addition, changes identified in these microarray analyses support a role for more generalized transcriptional dysregulation in toxicity of expanded repeat RNAs.
Tyrannosaurus may have acquired a larger percentage of meat from carrion sources than did smaller theropods, therefore filling the role of a more generalized, carnivorous opportunist such as a hyena.
SK-N-FI was the only cell line generating tumors with more generalized NESP55 immunoreactivity.
More suggestions(15)
more unifying role
more generalized wishing
more generalized recovery
more public role
more modest role
more commanding role
more female role
more generalized internist
more normal role
more generalized exponential-sum
more generalized model
more limited role
more pernicious role
more direct role
more generalized obesity
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