The absence of a significant treatment effect on global CBF provides confidence that treatment-derived BOLD signal changes were most likely driven via mechanisms of neurovascular coupling, rather than via a more generalized global increase in CBF (32).
In total, our results point to a more generalized concept with increased susceptibility to inflammation in the presence of hyperglycemia.
4 6 Currently, there is the potential for a more generalized epidemic if transmission increases outside of high-risk core groups., With an estimated adult HIV prevalence now exceeding 1%, this seems increasingly plausible.
Despite the specificity of ACPAs to rheumatoid arthritis, however, citrullination is a more generalized phenomenon - with increased citrullination seen in the synovial fluid of inflamed joints affected by spondyloarthropathy [ 4] as well as in inflamed muscle in myositis and [ 8] myelin basic protein in multiple sclerosis [ 9].
Such studies will be necessary in order to find out (i) whether or not the developmental DNA methylation changes reported here represent a more generalized, age-dependent drift towards increased methylaton levels and (ii) whether or not schizophrenia or Alzheimer's disease are associated with DNA methylation changes affecting wide-spread portions of the genome.
The results from both epidemiological and biological studies suggest that PTB may be a function of a more generalized pro-inflammatory process that increases the overall likelihood that some women will deliver prematurely [ 2, 7- 9].
Along come the predictable shock waves of human reactions: increased anxiety, shorter attention spans and more generalized irritability and anger -- usually accompanied by increased harsh judgment on yourself and others and by projections of ill intent on (and from) life partners, families, friends, co-workers and business partners.
Difference in UGA weight was likely due to more advanced/aggressive tumors and not to a generalized increase in body weight of TRAMPJα18−/− mice.
SK-N-FI was the only cell line generating tumors with more generalized NESP55 immunoreactivity.
During this period, however, there was also increasing evidence of a more generalized contamination of the environment caused by lead emissions from motor vehicles.
