Sentence examples for more generalized defect from inspiring English sources

We cannot exclude that this might reflect a more generalized defect in the splicing machinery with increased aging.

It was surprising that SPCS1 and SPCS2 mutations only impacted cell surface staining of ULBP1 and not the six other membrane proteins tested, as we had expected that mutating components of the signal peptidase complex would cause a more generalized defect in cell surface protein expression (see 'Discussion').

To see if our observation was specific to AJM-1 or reflected a more generalized defect in the epithelia of pha-1 (0 ) mutants, we examined expression patterns of several markers associated with adherens junctions and integrity in 1.5-fold pha-1 (0 ) embryos.

We were curious to know if the elongation defect in exocyst mutants was restricted to the elongation zone, or if it represented a more generalized defect (for example, a defect altering the basic structure and overall expansibility of the cell wall) that also influenced cell elongation in the meristem.

Proximal RTA may be isolated or a part of a more generalized tubule defect, named Fanconi syndrome, characterized by elevated urinary excretion of solutes like phosphate, uric acid, potassium, glucose, amino acids, and low-molecular-weight proteins [ 55].

This is consistent with the mutants having more generalized "cognitive" defects, which we now investigate further using electrophysiology.

SK-N-FI was the only cell line generating tumors with more generalized NESP55 immunoreactivity.

We have replaced speculations that TALPID3 (KIAA0586) mutant tissue exhibits PCP defects by with a more generalized statement that TALPID3 is required for normal tissue polarity, cell polarity and correct positioning of centrosomes in polarized cells (as appropriate).

hBMSCs can be either implanted in focal defects, or injected intra-articularly to repair more generalized cartilage lesions like osteoarthritis [4], [5].

Because downregulation of other complexes of the oxidative phosphorylation system was also observed, a more generalized reduction of mitochondrial respiration seems to be present in neuroblastoma in contrast to the single enzyme defect found in hereditary pheochromocytomas.

The more anxious the companies feel about profits, the more generalized the generalized anxiety disorders get.