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By contrast, there may be a more general reprogramming caused by EDCs, such that exposed individuals and their offspring have altered responses to environmental (proximate) stimuli that go beyond a single system (e.g., estrogenic EDCs) and affect a broader array of responses, including stress responsiveness, as we use as an example below.
Similar(57)
Similar modulation of the UPR observed in the tunicamycin-treated cells deficient in caspase-7 suggests that the caspase-7 has a much more general role than reprogramming the cellular signaling in T17M RHO photoreceptors and much broader potential applications in UPR regulation.
Our experiments suggest that this type of combinatorial repression further stabilized by mH2A may be a more general phenomenon since transcriptional reprogramming of Oct4 and Sox2 was also enhanced in the absence of mH2A.
Thus we speculate that a more general mechanism, rather than the expression of specific genes, might underlie the effect of stress-activated p38 on reprogramming.
However, the threat is rather more general.
He called this more general technique "correlation".
There was much more general participation then.
But the more general trend is resignation.
It filed a more general "white paper".
And perhaps a more general one.
It's just more general activity.
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