Repeating the questionnaire in other locations will identify if this is a Sydney-specific or more general outcome.
Similar contradicting results were found on more general outcome measures of physical functioning, provided by a health questionnaire that contained physical well-being and physical activity.
Reliable quality of life measurements, which constitute one of our prespecified outcome measures, could prevent in part measurement at symptom level and indicate how treatment influences a more general outcome.
Accumulation of hmFCCs and the existence of a split path of chlorophyll breakdown are, thus, not unique for ripening banana fruits, but are rather a more general outcome of chlorophyll catabolism in higher plants.
We initially considered having a more general outcome of "any haemorrhagic event" but decided against this given the disparate nature of the events, the rarity with which some occur, the lack of relevant ICD-10 codes for some outcomes, and the difficulty of applying definitions requiring clinical adjudication to routinely collected data.
Since we do not assume that the semigroup is compact and other conditions are more general, the outcomes we obtain here improve and generalize many known controllability results.
Furthermore to use a more general composite outcome reduces the risk of finding any effect, as other influences that determine the proportion of children who die or have developmental, neurological or sensory impairment may overwhelm or dilute a small effect from the treatment.
In the example of a recent large trial of magnesium sulfate for neuroprotection 9 the chosen end point was death or moderate/severe cerebral palsy rather than a more general impaired outcome; this was chosen because it was thought to be related better to the concept of neuroprotection.
In some studies disease-specific validated outcomes scores have been used, like the VISA score, while in other only more general non-validated outcomes like the VAS have been used.
These included suicidal behaviour (e.g., suicidal ideation/thoughts, plans of suicide, suicide attempts, suicide completion, self-harm), as well as more general mental health outcomes (e.g., depressive symptoms, hopelessness).
