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For more general mode-locking resonances, where q ≥ 2, Arnol'd showed in [ 31] that the width of the tongue satisfies: Δ α ∝ ε q.
While budding yeast (Saccharomyces cerevisiae) have usually been used in these types of studies, fission yeast (Schizosaccharomyces pombe) maintain many more of the basic cancer-relevant cellular processes present in human cells (e.g., cell division, DNA replication, and heterochromatin assembly), making fission yeast a potentially much more general model for mode of action studies.
More recently, Jaegwon Kim [1989] has revived this issue in a more general way, seeing the two modes of explanation as joint instances of a Principle of Explanatory Exclusion.
While three modes can often provide a reasonable local approximation to a more general model, the choice of which three is sometimes counter-intuitive.
Compared with the binary mixed-mode model, the newly developed GEB model is a more general mixed-mode model, and can physically describe the mixed-mode kinetics during the austenite-to-ferrite transformation in binary, ternary and even higher alloy systems.
While this classification scheme, being at least partly based on known molecular targets, could with some reason be called a mechanism-of-action classification [37], we used the more general term mode-of-action also when more detailed mechanistic information is available about the underlying biochemical processes.
We propose the MATHUSLA surface detector concept (MAssive Timing Hodoscope for Ultra Stable neutraL pArticles), which can be implemented with existing technology and in time for the high luminosity LHC upgrade to find such ultra-long-lived particles (ULLPs), whether produced in exotic Higgs decays or more general production modes.
Furthermore, a complex generic phase diagram has recently been developed rationalizing the membrane interactions of cationic amphipathic peptides by their molecular shape to explain in a more general sense the mode of action of these cationic amphipathic peptides (Bechinger and Lohner, 2006; Bechinger, 2009).
Whether more subtle changes in NEMO activity exist in RCC cells, and more general analysis of the mode of interaction of HIF-2 α with its endogenous target genes in RCC will require further investigation.
The results are developed for haploid island models with constant patch size, but the techniques demonstrated here would apply to more general scenarios with an island mode of dispersal.
The key measures "degree of difficulty of conversion" and "degree of exhaustion" are introduced to define the optimal modes in more general terms.
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