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This suggests that CNP reduction might be critical for a more general disease process and not restricted to a single diagnostic category.
One can hypothesize that this image of poor health, more general disease complaints and even negative self-esteem might result in a less optimistic view about the future, as we also see in the present study.
The hierarchal structure also allows more general disease terms to be distinguished from subclasses, in order to account for "over-mapping" of disease terms to a textually larger database.
These findings suggest that CNP reduction might be critical in a more general disease process and that the potential role of this molecule is not restricted to a single diagnostic category but of global relevance for severe mental disorders.
It could be also interesting to extend this study to other pathogens for detection of disease resistance related QTL affecting turbot aquaculture systems in order to investigate more general disease resistance related traits.
Although we have presented results based on a multiplicative disease risk assumption within each sub-phenotype class, applied to directly observed genotypes, the multinomial regression model can easily be extended to incorporate more general disease models by incorporating dominance, and can be utilized with imputed data.
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This mapping preserved individual diseases but rooted them in a hierarchical vocabulary, allowing a user to cluster what might at first appear to be unrelated diseases (e.g., "Papillon-Lefevre syndrome" and "multiple café-au-lait spots") via a more general parent disease (e.g., "skin diseases").
We propose a hierarchical structure using Dempster-Shafer at the upper level for evaluating more general hypothesis (disease groups) and Bayesian networks at the lower level for a more accurate analysis of specific diseases.
Of particular interest is the identification of lupus-specific versus more general autoimmune disease genes and the exposures that trigger flares for particular genomic profiles.
The NYHA is a more general cardiac disease rating scale, which is similar to CCS, but not completely consistent with it [See Additional File 1] [ 25].
We have provided further discussion of the genetics of MDD, and the role that studies of familial disorders have played in the elucidation of mechanisms and circuits that are relevant to more general, sporadic diseases (see Discussion).
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more general illnesses
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more active disease
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more erosive disease
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more challenging disease
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