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However, other more general cellular defects due to the absence of CRT in the fibroblasts, such as cell adhesion deficiencies, were not fully restored.
From a SAGE analysis, we identified 57 Anopheles gambiae genes differentially expressed in the salivary glands of infected female mosquitoes and showed that, as in the midgut, Plasmodium invasion is accompanied by an innate immune response as well as more general cellular responses [15].
However, most adaptively evolving proteins are found to perform more general cellular functions.
Other positively selected proteins influencing cell signaling activity perform more general cellular functions.
However, these genes are associated with more general cellular functions and are present in both pathogenic and non-pathogenic Bacteria.
These enzymes do not have a specific role in the circadian clock but have a more general cellular function.
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For example, at a depth of 5 in the biological process GO, the term "regulation of sister chromatid cohesion" (GO 0007063) with a single indirect gene product annotation appears alongside a much more general term "cellular protein metabolism" (GO 0044267), which has 1381 annotations.
For example, imposex is considered to be a highly specific effect, responding primarily to organic tin compounds such as tributyltin (TBT), whereas lysosomal stability is a more general biomarker for cellular stress.
While, it remains unclear whether THz radiation is influencing specific genomic functions or whether the impact is more general resulting in cellular damage, it is apparent that the mechanisms by which the non-ionizing THz radiation influences biological functions must be fundamentally different from those at play when high-energy (UV, x-ray, gamma, etc).
This opens up an intriguing scenario where the deregulation of key pathways for tumorigenesis represents only the final step of a more general perturbation of cellular activity.
Thus, this pattern is not restricted to a small set of well-studied biomarkers, but instead appears to be a more general characteristic of cellular physiology.
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