Sentence examples for more gene segments from inspiring English sources

However, HA can change to evade previously acquired immunity either by antigenic drift, whereby mutations of the currently circulating HA gene disrupt antibody binding, or by antigenic shift, with the virus acquiring an HA of a new subtype by re-assortment of one or more gene segments.

We were unable to obtain sequences for one or more gene segments from nine of the 46 species sampled.

Sequence analysis of multiple clones of cDNA fragments derived from one or more gene segments has also been used to study sequence variation of influenza virus derived from clinical samples [ 15, 16].

However, if we restrict to intersegment regions adjacent to long (three or more gene) segments, we find that the insulators BEAF-32, CP190, CTCF, and Su(Hw) are significantly enriched by factors of 1.30, 1.23, 1.19, and 1.23 respectively (Additional file 3: Table S4), as compared to the rest of the genome (excluding peaks overlapping the interaction domain windows).

Antigenic shift occurs when the virus acquires an HA of a different influenza subtype via reassortment of one or more gene segments and is thought to be the basis for the more devastating influenza pandemics that occurred several times in the last century[ 4].

We analyzed gene orientation for adjacent pairs of genes and found that two-gene segments are enriched for "head-to-head" gene pairs, which may be regulated by a bidirectional promoter [ 49], relative to pairs flanking intersegment regions (P = 1.24e-6) or adjacent pairs within longer (three or more gene) segments (P = 0.0021).

Because the 1918 gene segments have more synonymous changes from known sequences of wild bird strains than expected, they are unlikely to have emerged directly from an avian influenza virus similar to those that have been sequenced so far.

Conversely, there were ProbeSet IDs with multiple annotations (EntrezID/Gene Symbol) due to sequence identity across more than one gene segment in the genome.

The non-clonal evolution of influenza viruses comprises relatively frequent reassortment among gene segments and a more rarely reported process of non-homologous RNA recombination.

In the second stage of homologous searching, more than 92% of the gene segments, which were most similar to other arthropod sequence, were excluded.

However, individual V H gene segments were used more variably (p = 0.90, R2 = 0.25).