We also found that RNA-seq is more sensitive in reproducibly detecting alterations in gene expression, detecting more genes altered at lower quantitative levels (Additional file 1: Table S1; 5 > 2 fold).
Conversely, females showed more genes altered at higher doses, and had only 43 transcripts altered at all four doses (Fig. 2e).
More genes altered expression patterns in male mutant mice compared with female mutant mice at 6 month of age (both in numbers and fold).
Our data are in agreement with previous reports demonstrating an increase in inflammatory genes in both adipocyte populations with age, and in particular in the bone marrow, since the pathway analysis indicated that there were more genes altered with age in bone marrow adipocytes.
In fact, the only gene altered more frequently in this malignancy is VHL, a well-characterized driver of these cancers.
As single 51B cells spontaneously appeared in the 51D cultures and were selected by immobilization, these differences suggest that the altered SAg, specific for the serotype, is not the only DEG but many more genes show altered gene expression.
The European Commission, however, wants to allow more gene-altered products into the Union to remove an irritant in trade relations with the United States and other countries that use them — and to lower costs for European farmers and industry.
These facts fit well with the fact that more genes were altered in autumn with STI compared to spring, but also suggest that this transcriptional regulation may be of epigenetic origin.
When PV serum was used for 24 h, the expression of even more genes was altered.
The results showed that more genes were altered in H460/TaxR cells compared with H460 cells (Supplementary Figure S3c).
However, ANOVA did reveal that considerably more genes were altered in their expression due to the mouse background (493 genes) compared to chance alone (p < 0.01).
