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Many more, functionally essential oncoproteins could thus become useful drug targets.
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In contrast, a non-essential gene can be considered more functionally dispensable and/or redundant [ 70].
Proteins involved in multiple pathways have more interactions with other proteins and tend to be functionally essential [ 58, 59].
These fail to complement the male-sterile alleles and are likely to be larger deletions including a functionally essential portion of the Ntl gene and extending further into one or more essential genes.
The more conserved genes might have undergone high selective constraint against changes in the REST sites, and are functionally essential.
This was anticipated in accordance to a rule of "the more conserved, the deeper regulated" has been proposed in protein-protein interaction networks, in which hubs or central proteins are functionally essential and usually lethal after gene knockout [ 27].
Now, she said, the boy is becoming more functionally independent.
Cell-substrate interaction was functionally essential for phenotypic maintenance and multipotency remodeling of stem cells.
These changes have led a more functionally rich cheminformatics library, with significant performance improvements.
Family structures and labour demands have re-arranged, often resulting in more functionally single-headed households.
These antibody responses are functionally essential to maintain host-commensal mutualism in vivo in the face of innate immune deficiency.
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