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The characterization of USP4/15 and USP4/11 duplications as WGD and SSD, respectively, corroborates well with reported trends for these phenomena: SSD-derived paralog sequences tend to evolve faster and are more functionally divergent [ 65].
If that was the case then we would expect that the GroEL protein copy that is more functionally divergent from the ancestral GroEL should show lower mean MIC values when tested against each protein set, indicating lower mean coevolution with these GroEL protein clients.
Genome-wide comparisons of the ratio of the nonsynonymous substitution rate to the synonymous substitution rate (dN/ dS) also indicate that male-biased genes are more functionally divergent between closely-related Drosophila species and are less likely to have identifiable orthologs between distantly-related species than genes with female-biased or unbiased expression [ 2, 4].
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Type III J-proteins are more structurally and functionally divergent and involved in protein translocation [ 12].
Our data suggest that the TOC1/PRR1 orthologs in S. moellendorffii, O. sativa and Arabidopsis represent a more recent and functionally divergent variant among the two component pseudo-response regulators.
However, these CtFAD2 genes are possibly more likely to be performing reactions other than oleate desaturases, considering that their primary sequence features are more closely associated with functionally divergent FAD2 homologs and they were unable to synthesise linoleic acid when expressed in yeast.
Thus, functionally divergent genes might contribute to the phenotypic divergence in xylem formation.
The CaMK are an important family of S/T-specific kinases with functionally divergent roles, which are represented by five O. tauri genes and thirteen CaMK-like genes that are more distantly related (Additional file 5: Table S2).
Now, she said, the boy is becoming more functionally independent.
WD-repeat proteins are a class of functionally divergent molecules that cooperate with other proteins to regulate cellular processes.
Bayesian inference of the evolutionary constraints imposed on functionally divergent proteins can reveal key components of the molecular machinery and thereby suggest likely mechanisms to test experimentally.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com