Sentence examples for more functionally constrained from inspiring English sources

This was expected as coding sequences are expected to be more functionally constrained than noncoding sequences.

In the Elliptochloris/ Choricystis clade, protein-coding genes show a greater range of variation in G+C content at third codon positions compared with the more functionally constrained first and second codon positions (supplementary fig. S5, Supplementary Material online).

Whole-genome studies have shown that highly connected network elements (e.g., nodes) tend to be more functionally constrained than nodes with fewer connections in both metabolic and protein protein interaction networks (Hahn et al. 2004; Vitkup et al. 2006).

Another factor that has been suggested to influence a protein's evolutionary rate is its number of interaction partners, with recent studies claiming that interactive proteins evolve more slowly because they have more functionally constrained residues [ 5, 6].

Further, this ontogenetic convergence among species of European Hydromantes suggests that adult foot morphology may be more functionally constrained than that of juveniles, a hypothesis that was previously suggested for these species [ 34].

Indeed, the nucleotide diversity at these sites within the C. reinhardtii ptDNA exceeds that of the more functionally constrained positions, such as first and second codon positions and rRNA-coding sites.

Here we characterize insect tubulin evolution, to identify events that release tubulins to evolve, and to more generally serve as a model for the evolution of functionally constrained proteins.

The upward bias on biochemical functionality estimates imposed by technical limitations is even more of an issue with histone marks, where even the resolution of the assay is not that much of a problem as is the fact that a single enhancer or promoter with a limited number of functionally constrained bases pairs can induce changes in the chromatin state of several neighboring nucleosomes.

But that's the machinery conserved across existing biological species changes to it, especially its functionally constrained domains, have (almost) inevitably been detrimental to an organism's survival.

These large host receptor molecules are in turn functionally constrained and thus conserved across species barriers.

Several oligonucleotides seem to evolve in this way, including transcription factor/protein-binding and functionally constrained palindromic and repeated DNAs.