In principle, SeqFEATURE can be applied to build models for other sequence-oriented motif databases, such as Pfam or PRINTS [ 36], to generate many more functional site models quickly and automatically, greatly increasing FEATURE's coverage of protein function space.
This week, Women Also Know Stuff moved to a new, more functional site.
Since all 13 SNPs and 5 INDELs in idh showed a similar magnitude of effect, we inspected their LD in an attempt to determine whether they were likely to represent one or more functional sites.
There are ≈ 26 Mbp in all exons of C. elegans [ 90]; this value has to be corrected, since we are not interested in synonymous sites and there are probably about three times more functional sites in noncoding DNA than in coding DNA [ 91- 94], suggesting a total of G ≈ 70 Mbp functional sites per haploid genome.
Another variant found at the 3' untranslated region, rs10954213, has been reported to create a more functional polyadenlyation site, which creates a more stable transcript [ 101].
The functional active sites of these two enzymes were quantified using the single turnover substrate DNPFG, and consistent with the hydrolytic activity, ∼5 7% more functional active sites were quantified with Vela than with Imig (Table 1).
Following induction, ESE-1 can directly activate IL-1-induced promoters by binding to two or more functional Ets sites [ 3].
Because evolutionarily conserved sites may be more functional than nonconserved sites [51], [52], this observation suggests that the tissue-specific binding sites are more likely to be functional than the binding sites that are shared in multiple tissues.
ERBB2-specific primer sets ERP1/2 and ERP3/4 gave a statistically significant enrichment; however, the pair amplifying the larger fragment (ERP3/4) yielded a greater percentage, suggesting the presence of more than one functional site for MBP-1 in the target region or, alternatively, a more efficient amplification.
In addition, there undoubtedly remain more functional MrpC binding sites to be found.
As the anonymous tipster who contacted TC noted: "It still looks like shit, but I guess it makes the site more functional".
