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This observation may account, in part, for our ability to identify many more functional regulatory variants in the baboons than we expected based on previous studies in humans.
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This unique dataset will be increasingly useful as more functional information and regulatory networks are defined, and can be interrogated as needed.
Interestingly, our algorithm identified more target genes that are annotated with known functions, indicating that our approach provides more functional information about transcriptional regulatory program.
This algorithm identifies the most conserved nucleotide motifs within a set of homologous DNA sequences, under the premise that functional regulatory elements are more highly conserved under natural selection than non-functional DNA sequences [29].
Gene classes (functional regulatory or transcriptional) rarely shared more than one or two paralogous relations regardless of the overall proportion of retained paralogs.
It has been shown that the sequence in functional regulatory regions of the DNA is more conserved than the surrounding non-functional regions [9].
In other words, large proteins would be subject to more regulatory signals but would not have more functional targets.
Regions of intergenic sequence which are more highly conserved than the surrounding background DNA would be strong candidates for such functional regulatory features.
As more functional genomics data collected over successive developmental stages become available, it will be possible to model the gene regulatory landscapes of different developing tissues.
The restaurant is more functional than fancy.
Elbaz takes a more functional view.
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