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Alternatively, MCF-7 cells might encompass more functional redundancy through expression of various motor proteins than in HeLa cells.
The reasons for this discrepancy are unclear but may be related to differences in the more complex in vivo infection model that allows for more functional redundancy and is biologically more relevant.
Although knockouts are easier to generate, negative regulators appear in general to display more functional redundancy than positive regulators of TCR signaling (the opposite may be true in B cells).
The same study found that 77%% of the plants were adapted for bird dispersal, but with eight extant fruit-eating birds in this archipelago, this guild probably has more functional redundancy.
Indeed, as we show in figure 2 A, the group I duplicate gene pairs have more functional redundancy because they share significantly more epistatic interaction partners than the group II duplicate gene pairs (P = 7 × 10−4), which is consistent with a recent study (Li, Yuan, and Zhang 2010).
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To more accurately analyze functional redundancy in the rice genome, we have developed a phylogenomics databases for six large gene families in rice, including those for glycosyltransferases, glycoside hydrolases, kinases, transcription factors, transporters, and cytochrome P450 monooxygenases.
Maintaining a larger genome and gene set provides more opportunities for functional redundancy and alternative pathways which can lead to a relatively smaller number of essential genes.
Compared with the previous version of RKD, RKD 2.0 enables more effective estimations of functional redundancy or dominance because it uses comprehensive expression profiles rather than individual profiles.
RpfE is one of five resuscitation factors identified in M. tuberculosis and although initial studies suggested functional redundancy more recent research suggests that these genes may have some degree of functional specialization [34], a notion supported by our data.
Perhaps even more common is the functional redundancy at the level of regulatory and metabolic networks 2, 90, 92, 93.
In Arabidopsis, the genetic robustness of cell cycle-related processes was found to be due to functional redundancy more than high selective constraint [ 29].
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