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Such data will provide one more functional genomics approach to pinpoint the disorder mutation.
In addition to the types of data already mentioned, more and more functional genomics data sets are becoming available in various data sources.
As more functional genomics data collected over successive developmental stages become available, it will be possible to model the gene regulatory landscapes of different developing tissues.
Nonetheless, we expect that the availability of more functional genomics data sets for humans, such as protein binding microarray data (Badis et al. 2009) and tissue-specific eQTL data, will likely make the problem of mapping DNA sequence change to gene expression change in humans more tractable in the near future.
The genome factor hypothesis postulates that the functional constraint can be decomposed into a number of biological factors; but the factor-list would be endless as more functional genomics data are becoming available and more factor-factor interactions have to be considered.
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Grains represent the most valuable organ of common wheat, and have been the subject for numerous genetic, breeding, and more recently, functional genomics studies [ 32, 33].
In contrast to current strategies where a targeted therapy could be randomly assigned to a patient who might or might not be screened to confirm the presence of a particular actionable genetic lesion, incorporation of the zebrafish xenograft platform could provide a more practical functional genomics readout with real time in vivo response data, which could be followed by genomic validation.
More comparative and functional genomics studies comprising SBSEC genomes are necessary that will cover additional species of the complex, like the recently sequenced Streptococcus lutetiensis[ 71].
The dark-eyed junco (Junco hyemalis) is a classic avian system that has been extensively studied for more than a century and will be made even more useful with functional genomics.
Genetic engineering has emerged as a method with high potential to modify traits more precisely and enable functional genomics studies more efficiently.
Germany's main opposition party, the Christian Democrats, has called for even more funding for functional genomics research, as has the nation's main basic research granting agency, the Deutsche Forschungsgemeinschaft. Related sites.
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