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Tissue-specific genes are longer than housekeeping genes because they have more functional domains, which is an indication of their more-complex protein architecture.
For functional characterization, GABAB1k, l, and m were chosen because they have more functional domains than GABAB1n.
The FACT-C questionnaire investigates more functional domains like QLQ-C30.
In yeast, retained duplicates have longer proteins and more functional domains than singletons [ 52].
One can observe proteins having two or more functional domains with different active sites [ 44].
F3'5'Ha, -c, -e, and -h are truncated in the PN40024 genome, and lack one or more functional domains [see Additional file 9].
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As shown in Table 1, HHpred outperformed 'hmmpfam' with 10% more functional domain coverage and 20% higher residue coverage in the human proteome against Pfam-A families.
For example, structurally ordered peptide regions are known to evolve more slowly than disordered regions (Brown et al. 2010), for the former usually contain more functional protein domains (Ponting and Russell 2002) and are supposedly subject to stronger functional constraints.
Moreover, as Hsp70 binds to the cellular caspase recruitment domain (CARD) domain of Apaf-1, it is expected to have one or more common functional domains between the CARD motif and aa 128 165 region of the M1 protein.
They also contain more divergent functional domains, such as the TPR domain, the WD-40 repeat, the U-box domain and the Zinc finger, each of which is involved in protein-protein or protein-DNA interactions.
Although more N-terminally located truncating mutations might be expected to give rise to more severe phenotypes by disrupting more of the functional domains, no genotype-phenotype correlations are apparent with respect to the location of truncating mutations in RAB23.
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more functional criteria
more functional uses
more dynamic domains
more general domains
more complex domains
more functional groups
more functional grounds
more collective domains
more functional hubs
more functional patients
more continuous domains
more functional devices
more functional rules
more structural domains
more complicated domains
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