Sentence examples for more functional constraint from inspiring English sources

Five gene lineages, including RNase4, RNase10, RNase12, RNase1, and RNase13, appear to have evolved under more functional constraint than the other gene lineages.

By analogy to peptide sequences, the observation that the positions in functional non-coding DNA with high information content evolve more slowly is consistent with these positions being more important for the formation of the protein-DNA complex, and therefore under more functional constraint.

We conclude that PPARα is adapted to hibernation in bats based on the observations that Pparα has a more stringent functional constraint in the ancestral lineage of hibernating bats and a higher level of expression in hibernating than in non-hibernating bats.

And, in general, there appears to be a significant trend towards shorter proteins in the absence of other, more specific functional constraints.

The results suggested that both domains were under differential selective pressures and the GST_C domain might have been subjected to more relaxed functional constraints.

For all the organisms studied, there seems to be a significant evolutionary trend favoring shorter proteins in the absence of other, more specific functional constraints.

Our results therefore indicate that NRPS domain evolution is influenced more by functional constraints acting on the domains, than by the evolutionary relationships between strains.

In polyploid clawed frogs, duplicates generated by WGD are subject to more severe functional constraints than the neutral expectation, even though these constraints are relaxed relative to a singleton gene [this study; [ 32, 40- 42]].

Thus, both more relaxed functional constraints in the GST_C domain and high degree of expression divergence should be regarded as the major mechanisms to facilitate the retention of duplicated genes and the adaptability to the diversity of potential xenobiotics and stressors.

Coding fRNAs may have a stronger effect on evolutionary rates at synonymous sites than at nonsynonymous sites, because there are many more sources of functional constraint for nonsynonymous sites, thus requiring a survey with greater statistical power to understand the more subtle influences of coding fRNA on nonsynonymous rates.

A beneficial effect would be expected if the early and fast proliferating CTL targeted persistent epitopes, which have been associated with more functional or structural constraints [18].