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However, insulin-treated patients suffered more functional alterations than those under non-insulin therapy, as shown in Fig. 3A.
Similar(59)
What are the features of a realistic background model that allow for the identification of statistically significantly recurrent and therefore more likely functional alterations?
Gene polymorphism can also be included on the extended list if it is characterized by more subtle functional alterations in the gene that still result in qualitative or quantitative alterations of the encoding protein (or noncoding RNA).
A gene polymorphism can be also included into the extended list if: It is characterized by more subtle functional alterations in the gene that, however, still result in qualitative or quantitative alterations of the encoding protein (or noncoding RNA) It is associated only with conditions that substantially increase the risk of cancer (ie, not associated with the risk of cancer).
More importantly, the brain functional alterations induced by training were found in the fusiform gyrus for both tasks.
By contrast, no suppression of sae2∆ camptothecin hypersensitivity was observed by mutating His37 to Ala (mre11-H37A; Fig 2G), suggesting that the effects of the mre11 SUPsae2 ∆ alleles were not mediated by the abrogation of a specific function of His37 but more likely reflected functional alteration through introducing bulky amino acid side chains.
Muscle strength has been shown to be more relevant to functional alteration than muscle mass in several studies [ 41].
This suggests either a common functional change or defect within these mutants with respect to the ability to cure [ URE3] or that more than one functional alteration in Sse1 can impair [ URE3] curing ability.
Mapping the location of the mutants onto the Sse1 crystal structure suggests that more than one functional alteration in Sse1 may result in changes in prion propagation and ability to function at elevated temperatures.
In the present study, as well as in the study of Tung and Kiyak (1998) [ 23], parents were found to be more concerned with aesthetic conditions than functional alterations stemming from malocclusions.
In addition to antibody-based detection techniques of global O-GlcNAc-pattern identification, recently more and more studies emerged, investigating into sequence-specific localization of functional alterations caused by protein modification with O-GlcNAc.
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