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At the time of treatment failure, patients with ≥5 CTCs/7.5 ml more frequently developed new metastatic lesions and sites compared with those with <5 CTCs/7.5 ml (development of new lesions: P = 0.0002; development of new sites: P = 0.0031).
Ascorbic acid deficient animals more frequently developed cholesterol gallstones [ 5, 6].
Also, patients with marked hyperglycemia at admission more frequently developed hyperkalemia than patients with normoglycemia (Table 6).
Very obese patients more frequently developed skin and soft tissue infections and were less likely to have pneumonia.
Moreover, the cohort studies indicated that, in postmenopausal women, CRC more frequently developed in the proximal colon than in the distal colon [ 40, 41].
Although patients in the derivation cohort were younger, they more frequently developed postoperative delirium, yet this did not reach statistical significance.
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Although males more frequently develop Internet gaming disorder (IGD) as compared with females, few studies have examined gender-related neurocognitive differences in IGD.
Affected individuals are predisposed to develop neoplasms, and more frequently develop adenocarcinomas of the colon [ 29].
Furthermore, animal experiments have shown that animals deficient in vitamin C more frequently develop gallstones [ 5, 6].
Conversely, patients with known sarcoma or melanoma more frequently develop solitary lung metastases than primary bronchogenic carcinoma (see Fig. 2)[ 5].
It might be that left sided and rectum tumors could modify the penetrance of chromosome 20q and as result more frequently develop liver metastases.
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