PCI-negative (PCI-) genes exhibit higher evolutionary rate and narrower expression breadth than PCI+ genes (p<0.001), consistent with more frequent tissue-specific inactivation.
This may reflect, on the one hand, the general restoration of oxygen-transport capacity by Hb induction and, on the other hand, tissue-specific variations in cellular oxygen supply with more frequent episodes of tissue hypoxia, especially in the body core region.
Heteroplasmy has been detected in many species [ 23], and some studies in humans have shown it increases with age in somatic cells and is more frequent in certain tissues, such as muscle tissue, most likely because of increases in the number of mutations caused by the presence of oxidative radicals [ 23, 24].
CD1a+ cells (immature DCs) were more frequent in NSCLC tissues as compared to peritumoral lung tissue, while CD83+ cells (mature DCs) were more frequent in peritumoral lung tissue.
When we examined the 62 GC specimens and the corresponding adjacent noncancerous tissues, cells showing the diffuse cytoplasmic LC3A staining were significantly more frequent in GC tissues (P = 0.040) compared with the adjacent noncancerous tissues (Fig. 2C).
The loss of RASSF1A protein expression (51.32%) was found to be more frequent in tumor tissues compared to the other two groups.
Parallel observations have been made independently in mice, where large H3K9me2-marked regions are more frequent in adult tissues in comparison with mESCs [ 80].
In light of personalized therapeutics, this observation that EphB4 overexpression is more frequent in epithelioid tissues is important for clinical study design with therapeutic compounds targeting EphB4 and consideration to select appropriate cases.
Cancerous tissues exhibited more frequent methylation of KEAP1 than normal tissue in surgically resected CRC specimens.
Our results in pathology indicated that high expression of each of these three markers was much more frequent in human colorectal cancer tissues than in normal tissues or non-tumor lesions.
In a recent study, detection of HBV DNA in B-NHL tissues was more frequent than in T-cell NHL or other lymphatic system disease tissues, suggesting that chronic HBV infection in lymph nodes might be associated with B-NHL [ 14].
