Our results provide evidence that the expression pattern of nuclear Survivin was similar between primary and secondary GBMs, but, in contrast, cytoplasmic Survivin positivity was significantly more frequent in primary GBMs than that in secondary GBMs.
In the third trimester, progressive pain dynamics occurred more often in secondary headache (p = 0.014), while nausea and visual disturbance were more frequent in primary headache (p = 0.035 in both cases).
By contrast, another study reported that losses on 16q are more frequent in primary tumors than in metastases [ 15].
There are sparse data on the incidence, but it is probably more frequent than primary HLH [ 28].
Our results show that cytoplasmic Survivin positivity was significantly (P<0.001) more frequent in primary GBMs (83%) than that in secondary GBMs (46%).
These results suggest that PKC α overexpression is more frequent in primary tumours of patients who experience disease recurrence compared with patients who remain disease-free.
This further suggested that in addition to pre-schools, EV71 transmission has become more frequent in primary schools compared to the past decade.
We found that patients with vitamin D deficiency developed significantly more frequent second primary cancers than did patients with sufficient vitamin D concentration.
Analysis of groups of Kv10.1 expression showed significant differences regarding score 0 and 1 (see Methods for scoring; more frequent in primary tumors, p = 0.04 and 0.035, respectively) and score 2 (more frequent in brain metastases, p = 0.038).
Thus, if the above hypothesis has validity, it is not so difficult to understand why Survivin accumulation in cytoplasm is much more frequent in primary GBMs than that in secondary GBMs.
