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However, the PTBD group in that study had more advanced disease as evidenced by more patients with Bismuth type 4 tumors (30 vs. 14 %), more perioperative blood transfusions (31 vs. 9 %), and more frequent hepatic artery resections (22 vs. 9 %).
Compared with the HBsAg-negative group, the HBsAg-positive DLBCL group displayed a younger median onset age (46 year vs 51), more advanced stage at grade III/IV (58% vs 42%, p = 0.016), and more frequent hepatic dysfunction before (21% vs 5.5%, p < 0.001) and during (49.4% vs 16.6%, p < 0.001) chemotherapy.
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Elderly people are more frequent to show reduced hepatic and kidney function, frequently have comorbities requesting new therapies with a higher pill burden and higher risk of drug interactions.
HCCs usually arise against a background of cirrhosis or chronic hepatitis, whereas hepatic adenomas are more frequent in young women of childbearing age.
The types of AEs were consistent with those observed in studies of ipilimumab monotherapy; however, the incidence of hepatic AEs was more frequent than expected for ipilimumab alone at 10 mg/kg.
Increases in hepatic transaminase levels were more frequent with RVX-208 than placebo.
The most common adverse events associated with pazopanib, sunitinib, and bevacizumab plus IFNα are summarized in Table 7. Grade 3 hepatic toxicity may be more frequent with pazopanib than with other TKIs such as sunitinib.
No significant difference was observed in patient profiles or parameters related to each nodule, except history of TACE and preoperative severe hepatic arterial damage, which was more frequent in the nonwarmed miriplatin group.
Sepsis, hepatic toxicity and neuropathy were more frequent in ALL202-U, although no patient died from the adverse events associated with chemotherapy during post-remission therapy in this study.
Hepatic failure secondary to viral hepatitis was the most frequent hepatic event in our analysis.
All ARV drugs have been associated with development of Grade 3/4 ALT/AST elevations [ 11, 32]; and these events are more frequent in patients with HBV/HCV co-infection or increased baseline hepatic transaminase levels [ 11, 32- 34].
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