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Those with more severe underlying disease have more frequent exacerbations: in mild disease 1.8 per year, moderate 2 to 3 per year, and severe 3.4 per year.
Patients with chronic obstructive pulmonary disease experienced more frequent exacerbations on abatacept.
There was a trend to earlier exacerbation and more frequent exacerbations in subjects randomized to esomeprazole compared with placebo.
In addition, children with asthma whose parents smoke have more severe symptoms and more frequent exacerbations (IOM 2000).
Both low lung function and low anti-VP1 IgG1 levels were independent predictors of more frequent exacerbations.
Recently, we demonstrated that depressed COPD patients had a lower HRQOL and more frequent exacerbations and hospitalizations those non-depressed COPD patients [ 3].
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Increased bacterial colonization has been shown to lead to more frequent acute exacerbations of COPD (AECOPD) and worse outcomes from those exacerbations (15– 15).
The possibility that more frequent pulmonary exacerbations may lead to reduced regular physical activity is worthy of further investigation.
However, women present worse lung function with faster function decline, earlier onset of bacterial colonization, more frequent pulmonary exacerbations (PE), greater bronchial hyper-responsiveness, and higher mortality rates after puberty than men.
P. aeruginosa QS molecules correlate with clinical status in cystic fibrosis and are biomarkers for infection http://ow.ly/MhzZp The majority of adults with cystic fibrosis (CF) are chronically infected with Pseudomonas aeruginosa, which is associated with an accelerated decline in lung function [ 1], more frequent pulmonary exacerbations and increased mortality [ 2].
As the disease worsens, e.g. Gold 2+, patients also experience progressively more frequent and severe exacerbations, which are due in greatest part to bacterial and viral chest infections, as well as pollutants [ 6– 8].
More suggestions(15)
more frequent loads
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more moderate exacerbations
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more severe exacerbations
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more frequent data
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