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If this is your diagnosis (after a careful examination of your symptoms), your doctor may suggest a higher or more frequent dose of a class of medication called a proton pump inhibitor (such as Prilosec, Nexium, or Prevacid).
The more frequent dose changes cannot be explained by differences in the patient populations.
There were more frequent dose reductions and dose delays, which were responsible for lower relative dose intensities of 5-FU and vinorelbine than docetaxel.
Patients who had received the DS treatment showed a tendency to experience more frequent dose reductions, but the difference was not statistically significant (29/56, 51.8% in arm DS, 17/49, 34.7% in arm D, P=0.078).
TA7 homozygotes did not receive a lower median irinotecan dose, number of cycles (P-values ⩾0.25) or more frequent dose reductions compared to the other genotypes (P-values for trend; combination therapy: 0.62 and single-agent: 0.45).
Dose escalation from 5 days to 7 days, however, resulted in increased toxicity and more frequent dose modifications in both chemotherapy and radiotherapy particularly in the second half of the treatment schedule.
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Patients without heart risks may be safe even with more frequent dosing, these data suggest.
Reduced doses and more frequent dosing could dilute out the adverse effects and still produce some beneficial effects.
They could sleep through the night — a crucial improvement over conventional painkillers, such as morphine, which require more frequent dosing.
In some clinics, women with advanced breast or ovarian cancer are being given smaller, more frequent doses of chemotherapy to reduce side effects.
But giving Venofer, the iron drug, in smaller and more frequent doses would increase needle use, violating that policy.
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