Sentence examples for more frequent alterations from inspiring English sources

Unexpectedly, we found that tumors with the lower HER2 copy numbers had more frequent alterations in the PI3K pathway genes than those with the higher copy numbers (Table 1).

The 8 patients showed more difficulty in achieving pCR (P=0.019), more frequent relapse (P=0.018), and more frequent alterations of genes in the PI3K pathway (P=0.009) than the patients with HER2 amplification.

In fact, the significantly more frequent alterations to treatments or medication regimens on the part of nurses in the NC cohort indicates that the whole nursing team have more confidence in caring for patients, in which the professional leadership role of NCs may be a key factor.

Hence, great efforts are now aimed at finding efficient ALK inhibitors, at least for the more frequent ALK alterations.

Although there are significantly more frequent genomic alterations in the cell lines, the pattern of gain and loss is strikingly similar to that seen in the primary tumors.

The more frequent, milder alterations in brain function and chemistry in newly diagnosed DKA have been assumed to be transitory with normalization after metabolic stabilization (5– 8), but this assumption has not been formally tested.

Activating mutations in fms-like tyrosine kinase-3 (FLT3) represent one of the more frequent genetic alterations in AML (Rockova et al, 2011), involving internal tandem duplication (ITD) in the juxtamembrane (JM) domain of FLT3 (Nakao et al, 1996).

Taken together, our data reveal more frequent and complex alterations of ETS genes than previously recognized and identify key genes like EZH2 and Nkx3.1 contributing to the reprogramming of prostate epithelial cell transcriptome in response to aberrant expression of oncogenic and tumor suppressor ETS factors.

RNH occurred in 22 of 146 patients (15%) and was more frequent than sinusoidal alterations (11%; Fig.  2).

Since copy number alterations were more frequent in tumors with less photoreceptorness, genomic alterations might be drivers of tumor progression.

These data show that the most common alterations involve whole chromosome arms arm-level arms arm-levele more frequent thalterationsdy in some studies (43)—are that breaks frequently localize adjacent to centromores.