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Exact(35)
Moreover, the more frequent administration of the IFNb preparation, as performed here, seems better than the administration of IFNb-1a just once a week [20, 21].
However, the consequences of missing a dose of a drug with less frequent administration may be more severe than for more frequent administration (Comté et al. 2007; Osterberg et al. 2010).
In people requiring hemodialysis, care should be taken to give linezolid after a session, because dialysis removes 30 40% of a dose from the body; no dosage adjustments are needed in people undergoing continuous hemofiltration, although more frequent administration may be warranted in some cases.
Another difference between groups included the more frequent administration of prednisone and methotrexate in RA patients.
Meropenem sequestration is also problematic and these data support a more frequent administration during ECMO.
It is, therefore, conceivable that inhibition of plaque formation and plaque resolution depends on a more frequent administration of curcuminoids.
Similar(25)
The clinical phenotype, rather than the age, represents the main variable able to determine the need of more frequent administrations of the drug at higher dosage.
The first clinical studies with TNP-470 explored weekly 1-h infusions, but as the terminal plasma half-life turned out to be only minutes, additional studies with either more frequent administrations or more protracted infusion schedules (up 120 h) were performed.
More frequent administrations may also be linked to adherence, as taking more than two doses of diabetes medication daily has been associated with higher A1C levels [ 29], and in a comparison of injectable GLP-1 receptor agonists, patients using once-daily liraglutide were more adherent than those using twice-daily exenatide [ 26].
There was a tendency for slightly more frequent ephedrine administration in the Nitrous oxide/TIVA group, but the difference was not statistically significant.
A more frequent intravenous administration schedule was considered to be unpractical, and limited bioavailability hampered the development of an oral compound.
More suggestions(15)
more legitimate administration
more junior administration
more progressive administration
more prolonged administration
more coherent administration
more friendly administration
more frequent monitoring
more early administration
more combative administration
more pliable administration
more developed administration
more frequent tinkering
more unified administration
more supportive administration
more effective administration
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