The impact of X-ray structure-based electrostatic calculations on the functional interpretation of these structural coordinates, on providing new explanations for experimental observations, and for the design of more focused additional experiments is illustrated by a number of key examples.
"The only way for this question to be properly answered," he says, "is with more thorough investigations and focused experiments".
"The more focused the experiment, the easier it is to see what works".
The experimental model employed 16 18 h serum-depleted cells, as these conditions were more apt for focusing experiments on self-produced VEGF and cholesterol roles, ruling out other growth factor effects.
Therefore, in exchange for complete absence of metadata we have created a robust gene-gene co-expression network which we demonstrate can outperform more focused, but smaller scale, experiments in many cases.
Krechevsky's experiments were more focused, more thorough in terms of the number of tested rats and collected trials per animal, and, as such, statistically more rigorous.
However, gametogenesis does not commence until well after hatching in chicken, therefore these experiments are more focused on the development of the gonad than on genes specific to gametogenesis.
It also helped to hypothesize about underlying mechanisms and possible downstream effects of certain groups of differentially regulated genes, thereby providing starting points for more focused follow-up studies or experiments.
"I've never seen a group of people more focused on optimization and engaged and interested in experimenting with art and tech and beyond.
Last year, we saw big banks like Chase, Wells Fargo and PNC experiment with branches that were smaller and more focused on digital technology.
